Tecfidera was studied in 2 clinical trials involving more than 2,600 people for 2 years each. In these studies, Tecfidera was compared against a placebo, or "fake" pill. This is a standard way to measure if a drug works as expected. Based on its clinical trials, Tecfidera was approved by the FDA to treat people with relapsing forms of multiple sclerosis. Find out more about trial results by clicking the green boxes below.
Call them relapses, flare-ups, or exacerbations. They're disruptive, and the goal is to reduce them. No MS medication completely gets rid of them, but people taking Tecfidera in a 2-year study had fewer relapses compared to placebo.
People with MS tell us how important it is for them to stay as active and mobile as they possibly can. That's why we studied physical ability in people over a 2-year period. What we learned is that Tecfidera helped delay physical disability progression in people with relapsing MS.
You don't necessarily feel brain lesions, but the fact they show up on an MRI scan means your MS has been active. We measured 3 different types of brain lesions, and for all 3 types, people taking Tecfidera had fewer lesions when compared to placebo over the 2-year study.
27% of people taking Tecfidera experienced relapse compared with 46% of people taking placebo, making them 49% less likely to experience a relapse.
This means that less than 3 out of 10 people taking Tecfidera experienced a relapse
During a clinical study, researchers looked at a sample of 152 people taking Tecfidera and 165 people taking placebo to understand the impact of Tecfidera on brain lesions. When you look at images of brain lesions, you can see different things depending on the age or stage of the lesion, the type of MRI, and whether dye is used during the test. Three different kinds of lesions were studied:
|When areas in your brain are being attacked, they become inflamed. These areas are “active” because the nerve cells are currently under attack. This kind of lesion disappears when the inflammation decreases.||This type of lesion is a scar that can tell you how big an impact MS has had on your brain over time. Sometimes these lesions can be new, and sometimes older ones can begin developing again.||Sometimes the body isn’t able to repair nerve cells in the brain, creating this type of lesion. This can mean a loss of function.|
A type of white blood cell that helps defend against infection.