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Benefits of Tecfidera

Tecfidera was studied in 2 clinical trials involving more than 2,600 people for 2 years each. In these studies, Tecfidera was compared against a placebo, or "fake" pill. This is a standard way to measure if a drug works as expected. Based on its clinical trials, Tecfidera was approved by the FDA to treat people with relapsing forms of multiple sclerosis. Find out more about trial results by clicking the green boxes below.

Reduced relapses

Reduced
relapses

Call them relapses, flare-ups, or exacerbations. They're disruptive, and the goal is to reduce them. No MS medication completely gets rid of them, but people taking Tecfidera in a 2-year study had fewer relapses compared to placebo.

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Delayed physical disability progression

Delayed physical
disability progression

People with MS tell us how important it is for them to stay as active and mobile as they possibly can. That's why we studied physical ability in people over a 2-year period. What we learned is that Tecfidera helped delay physical disability progression in people with relapsing MS.

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Slowed the development of brain lesions

Slowed the
development of
brain lesions

You don't necessarily feel brain lesions, but the fact they show up on an MRI scan means your MS has been active. We measured 3 different types of brain lesions, and for all 3 types, people taking Tecfidera had fewer lesions when compared to placebo over the 2-year study.

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Why it matters to ME
Having relapses can be a sign that my MS is active and may not be well controlled. Sure, they're often temporary, but during a relapse, it can feel like my life is on hold. Reducing my chance of having a relapse may mean fewer unpredictable disruptions that make living with relapsing MS challenging.
Why it matters to ME
For people like me, delaying the progression of physical disability is an important goal of MS treatment. That's because I want to maintain my current ability as long as possible.
Why it matters to ME
Quite frankly, the idea of having brain lesions is a little scary to me, especially because they can happen without any noticeable symptoms. Doctors can't say for sure if there's a link between brain lesions and the progression of MS. But they may look at brain lesions as a sign of silent disease activity and to help figure out how well treatment is working.

CloseReduced relapses

Fewer people taking Tecfidera had relapses

Relapse reductions over 2 years: percentage of people

Fewer people taking Tecfidera had relapses

27% of people taking Tecfidera experienced relapse compared with 46% of people taking placebo, making them 49% less likely to experience a relapse.

This means that less than 3 out of 10 people taking Tecfidera experienced a relapse

People taking Tecfidera had relapses less frequently

Relapse reductions over 2 years: frequency per year

People taking Tecfidera had relapses less frequently

CloseDelayed physical disability progression

Tecfidera delayed the progression of physical disability

Tecfidera delayed the progression of physical disability

38% fewer people had disability progression compared to those taking placebo over 2 years

CloseSlowed the development of brain lesions

Tecfidera slowed development of brain lesions

During a clinical study, researchers looked at a sample of 152 people taking Tecfidera and 165 people taking placebo to understand the impact of Tecfidera on brain lesions. When you look at images of brain lesions, you can see different things depending on the age or stage of the lesion, the type of MRI, and whether dye is used during the test. Three different kinds of lesions were studied:

  • • One shows active inflammation using a dye containing gadolinium (Gd+ enhanced)
  • • One shows the long-term impact of inflammation on your brain (T2 lesions)
  • • One shows damage that may be permanent (T1 lesions)

Tecfidera slowed development of brain lesions

When areas in your brain are being attacked, they become inflamed. These areas are “active” because the nerve cells are currently under attack. This kind of lesion disappears when the inflammation decreases. This type of lesion is a scar that can tell you how big an impact MS has had on your brain over time. Sometimes these lesions can be new, and sometimes older ones can begin developing again. Sometimes the body isn’t able to repair nerve cells in the brain, creating this type of lesion. This can mean a loss of function.

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