Common side effects of TECFIDERA

Learn more about common side effects and get tips that could help manage them

In clinical studies, the most common side effects of Tecfidera® (dimethyl fumarate) were:

TECFIDERA Common side effects: flushing

Symptoms are usually described as redness, itching, or rash.

TECFIDERA Common side effects: stomach problems
Stomach problems

Symptoms include nausea, vomiting, diarrhea, stomach pain, or indigestion.

Decrease in common side effects over time

In clinical trials, common side effects tended to happen earlier in treatment, and usually decreased over time.
Keep in mind that everyone is different and may react differently to the same medication.

Flushing side effect results chart
Stomach problems side effect results chart

Tips for handling the most common side effects

Call your healthcare provider if you have any questions about TECFIDERA side effects or treatment in general.

Tips to handle common side effects of TECFIDERA

Taking a non-coated aspirin (up to 325 mg) 30 minutes before taking TECFIDERA may help with flushing

Tips to handle common side effects of TECFIDERA

Food may help with flushing and stomach problems*

Tips to handle common side effects of TECFIDERA

Over-the-counter medicines may help relieve stomach problems*

*In a small 233-patient 12-week study, people recorded their experience of managing stomach problems while on TECFIDERA. They found that taking it with food or over-the-counter medications could help.

Find what works for you

Taking TECFIDERA with high-fat foods, like peanut butter, cheese, or yogurt may be particularly helpful with stomach problems. Visit the USDA website for more about how fats fit into a healthy diet.

Taking over-the-counter (OTC) medications, like antacids or aspirin might help with managing side effects. Talk to your healthcare provider or pharmacist for suggestions. Remember to read the directions on the package when taking any OTC medications and only take as instructed.

You could have other side effects. If they bother you or don't go away, or if you have general questions about side effects, talk to your healthcare provider.

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