What is TECFIDERA® (dimethyl fumarate)? • TECFIDERA is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults • It is not known if TECFIDERA is safe and effective in children under 18 years of age Please see Important Safety Information below and full Prescribing Information, including Patient Information. Hi ${user.firstName}, Thank you for registering with TECFIDERA—you will now receive updates as they become available. In the meantime, you can learn more here or by calling Biogen Support Services at 1-800-456-2255. Remember, your healthcare team is always your best source of information. Important Safety Information Who should not take TECFIDERA® (dimethyl fumarate)? • Do not use TECFIDERA if you have had an allergic reaction (such as welts, hives, swelling of the face, lips, mouth or tongue, or difficulty breathing) to TECFIDERA or any of its ingredients Before taking and while you take TECFIDERA, tell your healthcare provider if you have or have had: • low white blood cell counts or an infection • any other medical conditions Tell your healthcare provider if you are: • pregnant or plan to become pregnant. It is not known if TECFIDERA will harm your unborn baby ◦ If you become pregnant while taking TECFIDERA, talk to your healthcare provider about enrolling in the TECFIDERA Pregnancy Registry. You can enroll in this registry by calling 1-866-810-1462 or visiting www.tecfiderapregnancyregistry.com. The purpose of this registry is to monitor the health of you and your baby • breastfeeding or plan to breastfeed. It is not known if TECFIDERA passes into your breast milk. You and your healthcare provider should decide if you will take TECFIDERA or breastfeed • taking prescription or over-the-counter medicines, vitamins, or herbal supplements What are the possible side effects of TECFIDERA? TECFIDERA may cause serious side effects, including: • allergic reaction (such as welts, hives, swelling of the face, lips, mouth or tongue, or difficulty breathing) • PML a rare brain infection that usually leads to death or severe disability • decreases in your white blood cell count Your healthcare provider should do a blood test before you start treatment with TECFIDERA and while on therapy • liver problems. Your healthcare provider should do blood tests to check your liver function before you start taking TECFIDERA and during treatment if needed. Tell your healthcare provider right away if you get any of these symptoms of a liver problem during treatment ◦ severe tiredness ◦ loss of appetite ◦ pain on the right side of your stomach ◦ have dark or brown (tea color) urine ◦ yellowing of your skin or the white part of your eyes • herpes zoster infections (shingles), including central nervous system infections • other serious infections The most common side effects of TECFIDERA include: • flushing, redness, itching, or rash • nausea, vomiting, diarrhea, stomach pain, or indigestion • Flushing and stomach problems are the most common reactions, especially at the start of therapy, and may decrease over time. Taking TECFIDERA with food may help reduce flushing. Call your healthcare provider if you have any of these symptoms and they bother you or do not go away. Ask your healthcare provider if taking aspirin before taking TECFIDERA may reduce flushing These are not all the possible side effects of TECFIDERA. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA‑1088. For more information go to dailymed.nlm.nih.gov. Please see full Prescribing Information, including Patient Information. This information does not take the place of talking with your healthcare provider about your medical condition or your treatment. You received this email because you indicated that you want to receive information from Biogen, the sponsor of TECFIDERA.com. Your name, address, and other personally identifiable information you provide will not be sold to any third party. If you do not wish to receive information from TECFIDERA.com, please click here. Unsubscribe         Privacy Policy         Terms & Conditions         View in Browser ©2020 Biogen. All rights reserved. 12/20 TEC-US-1549 v5 225 Binney Street, Cambridge, MA 02142 • 1-800-456-2255 • TECFIDERA.com Do not reply to this message. This is a notification-only mailbox that cannot accept incoming email. This email is intended for residents of the US, Puerto Rico, and US territories.