In clinical studies, the most common Tecfidera® (dimethyl fumarate) side effects were:
Symptoms are usually described as redness, itching, or rash.
Symptoms include nausea, vomiting, diarrhea, stomach pain, or indigestion.
In clinical trials, common side effects tended to happen earlier in treatment, and usually decreased over time.
Keep in mind that everyone is different and may react differently to the same medication.
Call your healthcare professional if you have any questions about TECFIDERA side effects or treatment in general.
Taking a non-coated aspirin (up to 325 mg) 30 minutes before taking TECFIDERA may help with flushing
Food may help with flushing and stomach problems*
Over-the-counter medicines may help relieve stomach problems*
*In a small 12-week study, people recorded their experience of managing stomach problems while on TECFIDERA. They found that taking it with food or over-the-counter medications could help.
Find what works for you
Taking TECFIDERA with high-fat foods, like peanut butter, cheese, or yogurt may be particularly helpful with stomach problems. Visit the USDA website for more about how fats fit into a healthy diet.
Taking over-the-counter (OTC) medications, like antacids or aspirin might help with managing side effects. Talk to your doctor or pharmacist for suggestions. Remember to read the directions on the package when taking any OTC medications and only take as instructed.
You could have other side effects. If they bother you or don't go away, or if you have general questions about side effects, talk to your healthcare professional.